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1

A ‘Rule of Three’ for fragment-based lead discovery?

Miles Congreve, Robin Carr, Chris Murray, Harren Jhoti

Journal:

Drug Discovery Today

Year:

2003

Language:

english

File:

PDF, 24 KB

english, 2003

2

The inhibitory effect of a fermented papaya preparation on growth, hydrophobicity, and acid production of Streptococcus mutans , Streptococcus mitis , and Lactobacillus acidophilus : its implications in oral health improvement of diabetics

Somanah, Jhoti, Bourdon, Emmanuel, Bahorun, Theeshan, Aruoma, Okezie I.

Journal:

Food Science & Nutrition

Year:

2013

Language:

english

File:

PDF, 220 KB

english, 2013

3

Twenty years on: the impact of fragments on drug discovery

Erlanson, Daniel A., Fesik, Stephen W., Hubbard, Roderick E., Jahnke, Wolfgang, Jhoti, Harren

Journal:

Nature Reviews Drug Discovery

Year:

2016

Language:

english

File:

PDF, 3.52 MB

english, 2016

4

HIGH-THROUGHPUT CRYSTALLOGRAPHY FOR LEAD DISCOVERY IN DRUG DESIGN

Blundell, Tom L., Jhoti, Harren, Abell, Chris

Journal:

Nature Reviews Drug Discovery

Year:

2002

Language:

english

File:

PDF, 491 KB

english, 2002

5

The 'rule of three' for fragment-based drug discovery: where are we now?

Jhoti, Harren, Williams, Glyn, Rees, David C., Murray, Christopher W.

Journal:

Nature Reviews Drug Discovery

Year:

2013

Language:

english

File:

PDF, 106 KB

english, 2013

6

Discovering the Health Promoting Potential of Fermented Papaya Preparation—Its Future Perspectives for the Dietary Management of Oxidative Stress During Diabetes

Somanah, Jhoti, Putteeraj, Manish, Aruoma, Okezie, Bahorun, Theeshan

Journal:

Year:

2018

File:

PDF, 1.30 MB

2018

7

Discovering the Health Promoting Potential of Fermented Papaya Preparation—Its Future Perspectives for the Dietary Management of Oxidative Stress During Diabetes

Somanah, Jhoti, Putteeraj, Manish, Aruoma, Okezie, Bahorun, Theeshan

Journal:

Year:

2018

Language:

english

File:

PDF, 1.30 MB

english, 2018

8

Exploring substance use disorders and relapse in Mauritian male addicts

Ramsewak, Shalina, Putteeraj, Manish, Somanah, Jhoti

Journal:

Year:

2020

File:

PDF, 682 KB

2020

9

Detection of Ligands from a Dynamic Combinatorial Library by X-ray Crystallography

Miles S. Congreve, Deborah J. Davis, Lindsay Devine, Cesare Granata, Marc O′Reilly, Paul G. Wyatt, Harren Jhoti

Journal:

Angewandte Chemie International Edition

Year:

2003

Language:

english

File:

PDF, 230 KB

english, 2003

10

The Discovery of Novel Protein Kinase Inhibitors by Using Fragment-Based High-Throughput X-ray Crystallography

Adrian Gill, Anne Cleasby, Harren Jhoti

Journal:

Year:

2005

Language:

english

File:

PDF, 197 KB

english, 2005

11

High-Throughput Protein Crystallography and Drug Discovery

Ian Tickle, Andrew Sharff, Mladen Vinkovic, Jeff Yon, Harren Jhoti

Journal:

Year:

2005

File:

PDF, 8 KB

2005

12

Automated Protein–Ligand Crystallography for Structure-Based Drug Design

Wijnand T. M. Mooij, Michael J. Hartshorn, Ian J. Tickle, Andrew J. Sharff, Marcel L. Verdonk, Harren Jhoti

Journal:

Year:

2006

Language:

english

File:

PDF, 1.05 MB

english, 2006

13

Cover Picture: Automated Protein–Ligand Crystallography for Structure-Based Drug Design (ChemMedChem 8/2006)

Wijnand T. M. Mooij, Michael J. Hartshorn, Ian J. Tickle, Andrew J. Sharff, Marcel L. Verdonk, Harren Jhoti

Journal:

Year:

2006

File:

PDF, 33 KB

2006

14

Fragment-based screening using X-ray crystallography and NMR spectroscopy

Harren Jhoti, Anne Cleasby, Marcel Verdonk, Glyn Williams

Journal:

Current Opinion in Chemical Biology

Year:

2007

Language:

english

File:

PDF, 643 KB

english, 2007

15

High-throughput crystallography to enhance drug discovery

Andrew Sharff, Harren Jhoti

Journal:

Current Opinion in Chemical Biology

Year:

2003

Language:

english

File:

PDF, 268 KB

english, 2003

16

Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B

van Montfort, Rob L. M., Congreve, Miles, Tisi, Dominic, Carr, Robin, Jhoti, Harren

Journal:

Year:

2003

Language:

english

File:

PDF, 341 KB

english, 2003

17

Crystal structure of human cytochrome P450 2C9 with bound warfarin

Williams, Pamela A., Cosme, Jose, Ward, Alison, Angove, Hayley C., Matak Vinković, Dijana, Jhoti, Harren

Journal:

Year:

2003

Language:

english

File:

PDF, 462 KB

english, 2003

18

A new school for screening

Journal:

Nature Biotechnology

Year:

2005

Language:

english

File:

PDF, 194 KB

english, 2005

19

The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed to GDP determined from two different crystal forms

Greasley, Samantha E., Jhoti, Harren, Teahan, Carmel, Solari, Roberto, Fensome, Amanda, Thomas, Geraint M H, Cockcroft, Shamshad, Bax, Ben

Journal:

Natural Structural Biology

Year:

1995

File:

PDF, 1.63 MB

1995

20

Effects of a short term supplementation of a fermented papaya preparation on biomarkers of diabetes mellitus in a randomized Mauritian population

Jhoti Somanah, Okezie I. Aruoma, Teeluck K. Gunness, Sudhir Kowelssur, Venkatesh Dambala, Fatima Murad, Kreshna Googoolye, Diana Daus, Joseph Indelicato, Emmanuel Bourdon, Theeshan Bahorun

Journal:

Preventive Medicine

Year:

2012

Language:

english

File:

PDF, 319 KB

english, 2012

21

High-throughput structural proteomics using x-rays

Journal:

Trends in Biotechnology

Year:

2001

Language:

english

File:

PDF, 152 KB

english, 2001

22

High-throughput structural proteomics using x-rays

Journal:

Trends in Biotechnology

Year:

2001

Language:

english

File:

PDF, 152 KB

english, 2001

23

Protein–Protein Interactions: Putting the pieces together

Ben Bax, Harren Jhoti

Journal:

Current Biology

Year:

1995

Language:

english

File:

PDF, 408 KB

english, 1995

24

Structural genomics: lessons to be learnt

Journal:

Drug Discovery Today

Year:

2001

Language:

english

File:

PDF, 42 KB

english, 2001

25

Structure-based screening of low-affinity compounds

Robin Carr, Harren Jhoti

Journal:

Drug Discovery Today

Year:

2002

Language:

english

File:

PDF, 216 KB

english, 2002

26

High-throughput structural genomics and proteomics: where are we now?

Jeff Yon, Harren Jhoti

Journal:

Year:

2003

Language:

english

File:

PDF, 234 KB

english, 2003

27

Fragment-Based Lead Discovery Using X-ray Crystallography

Hartshorn, Michael J., Murray, Christopher W., Cleasby, Anne, Frederickson, Martyn, Tickle, Ian J., Jhoti, Harren

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 429 KB

english, 2005

28

Crystallization and Preliminary X-ray Diffraction Studies on ADP-ribosylation Factor 1

Samantha Greasley, Harren Jhoti, Amanda C. Fensome, Shamshad Cockcroft, Geraint M.H. Thomas, Ben Bax

Journal:

Journal of Molecular Biology

Year:

1994

File:

PDF, 143 KB

1994

29

Prothoracicotropic hormone has an insulin-like tertiary structure

H. Jhoti, A.N. McLeod, T.L. Blundell, H. Ishizaki, H. Nagasawa, A. Suzuki

Journal:

Year:

1987

Language:

english

File:

PDF, 563 KB

english, 1987

30

The epidermolytic toxins are serine proteases

Stephanie J. Dancer, Richard Garratt, Jose Saldanha, Harren Jhoti, Robert Evans

Journal:

Year:

1990

Language:

english

File:

PDF, 520 KB

english, 1990

31

A molecular model for the tumour-associated antigen, p97, suggests a Zn-binding function

Richard C. Garratt, Harren Jhoti

Journal:

Year:

1992

Language:

english

File:

PDF, 748 KB

english, 1992

32

A Structural Comparison of Inhibitor Binding to PKB, PKA and PKA-PKB Chimera

Thomas G. Davies, Marcel L. Verdonk, Brent Graham, Susanne Saalau-Bethell, Christopher C.F. Hamlett, Tatiana McHardy, Ian Collins, Michelle D. Garrett, Paul Workman, Steven J. Woodhead, Harren Jhoti,

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 1.95 MB

english, 2007

33

Detection of Ligands from a Dynamic Combinatorial Library by X-ray Crystallography

Miles S. Congreve, Deborah J. Davis, Lindsay Devine, Cesare Granata, Marc O′Reilly, Paul G. Wyatt, Harren Jhoti

Journal:

Angewandte Chemie

Year:

2003

Language:

english

File:

PDF, 229 KB

english, 2003

34

Crystallization and preliminary analysis of an 18,000 Mr fragment of duck ovotransferrin

H. Jhoti, B. Gorinsky, R.C. Garratt, P.F. Lindley, A.R. Walton, R.W. Evans

Journal:

Journal of Molecular Biology

Year:

1988

Language:

english

File:

PDF, 1.38 MB

english, 1988

35

High throughput protein crystallography: Developments in crystallisation, data collection and data processing

Marc O’Reilly, Mladen Vinković, Andrew Sharff, Harren Jhoti

Journal:

Drug Discovery Today: Technologies

Year:

2006

Language:

english

File:

PDF, 273 KB

english, 2006

36

Application of Fragment Screening and Fragment Linking to the Discovery of Novel Thrombin Inhibitors †

Howard, Nigel, Abell, Chris, Blakemore, Wendy, Chessari, Gianni, Congreve, Miles, Howard, Steven, Jhoti, Harren, Murray, Christopher W., Seavers, Lisa C. A., van Montfort, Rob L. M.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 291 KB

english, 2006

37

Crystal Structures of Thrombin Complexed to a Novel Series of Synthetic Inhibitors Containing a 5,5- trans -Lactone Template

Jhoti, Harren, Cleasby, Anne, Reid, Scott, Thomas, Pam J., Weir, Malcolm, Wonacott, Alan

Journal:

Year:

1999

Language:

english

File:

PDF, 165 KB

english, 1999

38

Novel Natural Product 5,5- trans -Lactone Inhibitors of Human α-Thrombin: Mechanism of Action and Structural Studies †

Weir, Malcolm P., Bethell, Susanne S., Cleasby, Anne, Campbell, Callum J., Dennis, Richard J., Dix, Clive J., Finch, Harry, Jhoti, Harren, Mooney, Christopher J., Patel, Shila, Tang, Chi-Man, Ward, Ma

Journal:

Year:

1998

Language:

english

File:

PDF, 188 KB

english, 1998

39

Relationship between fermented papaya preparation supplementation, erythrocyte integrity and antioxidant status in pre-diabetics

Somanah, Jhoti, Bourdon, Emmanuel, Rondeau, Philippe, Bahorun, Theeshan, Aruoma, Okezie I.

Journal:

Food and Chemical Toxicology

Year:

2014

Language:

english

File:

PDF, 425 KB

english, 2014

40

Diabetes as a risk factor to cancer: Functional role of fermented papaya preparation as phytonutraceutical adjunct in the treatment of diabetes and cancer

Aruoma, Okezie I., Somanah, Jhoti, Bourdon, Emmanuel, Rondeau, Philippe, Bahorun, Theeshan

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2014

Language:

english

File:

PDF, 1.91 MB

english, 2014

41

Molecular structure of serum transferrin at 3.3-.ANG. resolution

Bailey, Susan, Evans, Robert W., Garratt, Richard C., Gorinsky, Beatrice, Hasnain, Samar, Horsburgh, Christopher, Jhoti, Harren, Lindley, Peter F., Mydin, Assanah

Journal:

Year:

1988

Language:

english

File:

PDF, 1.07 MB

english, 1988

42

X-ray Crystallographic Studies of a Series of Penicillin-Derived Asymmetric Inhibitors of HIV-1 Protease

Jhoti, Harren, Singh, Onkar M. P., Weir, Malcolm P., Cooke, Robert, Murray-Rust, Peter, Wonacott, Alan

Journal:

Year:

1994

Language:

english

File:

PDF, 4.53 MB

english, 1994

43

A series of penicillin-derived C2-symmetric inhibitors of HIV-1 proteinase: structural and modeling studies

Wonacott, Alan, Cooke, Robert, Hayes, Fiona R., Hann, Michael M., Jhoti, Harren, McMeekin, Peter, Mistry, Anil, Murray-Rust, Peter, Singh, Onkar M. P., Weir, Malcolm P.

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 2.51 MB

english, 1993

44

[IEEE Thermal and Thermomechanical 10th Intersociety Conference on Phenomena in Electronics Systems, 2006. ITHERM 2006. - San Diego, CA (May 30-June 2, 2006)] Thermal and Thermomechanical Proceedings 10th Intersociety Conference on Phenomena in Electronics Systems, 2006. ITHERM 2006. - A Methodology for Thermal Evaluation of Strongly Bonded Packaging Materials

Stern, M., Kearns, D., Gektin, V., Jhoty, G.

Year:

2006

Language:

english

File:

PDF, 531 KB

english, 2006

45

[IEEE Twenty-Second Annual IEEE Semiconductor Thermal Measurement And Management Symposium - Dallas, TX USA (March 14-16, 2006)] Twenty-Second Annual IEEE Semiconductor Thermal Measurement And Management Symposium - Measurements of mechanical coupling of non-curing high performance thermal interface materials

Stern, M.B., Jhoty, G., Kearns, D., Ong, B.

Year:

2006

Language:

english

File:

PDF, 463 KB

english, 2006

46

High-throughput protein crystallography and drug discovery

Tickle, Ian, Sharff, Andrew, Vinkovi?, Mladen, Yon, Jeff, Jhoti, Harren

Journal:

Chemical Society Reviews

Year:

2004

Language:

english

File:

PDF, 322 KB

english, 2004

47

X-ray Crystal Structure of Human Dopamine Sulfotransferase, SULT1A3: MOLECULAR MODELING AND QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP ANALYSIS DEMONSTRATE A MOLECULAR BASIS FOR SULFOTRANSFERASE SUBSTRATE SPECIFICITY

Dajani, R., Cleasby, A., Neu, M., Wonacott, A. J., Jhoti, H., Hood, A. M., Modi, S., Hersey, A., Taskinen, J., Cooke, R. M., Manchee, G. R., Coughtrie, M. W. H.

Journal:

Journal of Biological Chemistry

Year:

1999

Language:

english

File:

PDF, 1.00 MB

english, 1999

48

Crystal structure of human CDK4 in complex with a D-type cyclin

Day, P. J., Cleasby, A., Tickle, I. J., O'Reilly, M., Coyle, J. E., Holding, F. P., McMenamin, R. L., Yon, J., Chopra, R., Lengauer, C., Jhoti, H.

Journal:

Proceedings of the National Academy of Sciences

Year:

2009

Language:

english

File:

PDF, 632 KB

english, 2009

49

High-throughput screening and structure-based approaches to hit discovery: is there a clear winner?

Jhoti, Harren, Rees, Stephen, Solari, Roberto

Journal:

Expert Opinion on Drug Discovery

Year:

2013

Language:

english

File:

PDF, 206 KB

english, 2013

50

Discovery of novel allosteric inhibitors of HCV NS3/4a enzyme via structure-based drug design

Pathuri, P., Saalau-Bethell, S. M., Woodhead, A. J., Carr, M. G., Chessari, G., Coyle, J., Frederickson, M., Graham, B., Hamlett, C., Hiscock, S. D., Holding, F. P., Jhoti, H., McMenamin, R., Murray,

Journal:

Acta Crystallographica Section A Foundations of Crystallography

Year:

2012

Language:

english

File:

PDF, 79 KB

english, 2012